As Cnollfan said, Crist and Meadow are excellent sources of the realities in the pick-6.
The #1 piece of advice I could give would be…
Partners:
The rub is they need to be…
- Serious
- Mature
- Honest
- Talented
- Ideally they have different handicapping disciplines from yourself and each other. If you can each specialize it goes a long way to eliminating the inevitable red-boarding that will bring stress to the arrangement.
There are at least 999 other variables with these complicated / expensive wagers and I wish you all the best.