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07-18-2021, 09:29 PM
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#9556
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Registered User
Join Date: Dec 2005
Location: Western NY
Posts: 5,345
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Quote:
Originally Posted by PaceAdvantage
BANG
Watch him squirm
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The box he thinks in is very small.
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07-18-2021, 09:58 PM
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#9557
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Registered User
Join Date: Dec 2001
Location: JCapper Platinum: Kind of like Deep Blue... but for horses.
Posts: 5,291
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The following article was picked up by both Nature and The Lancet.
It contains a review of several dozen studies showing Ivermectin to be effective against Covid-19.
In addition to the studies, the article contains a schematic drawing and explains how Ivermectin is effective against Cytokine Storm by inhibiting and disrupting binding of the SARS-CoV-2 S protein to ACE-2 receptors.
The mechanisms of action of Ivermectin against SARS-CoV-2: An evidence-based clinical review article:
https://www.nature.com/articles/s41429-021-00430-5.pdf
Quote:
Asiya Kamber Zaidi 1,2 ● Puya Dehgani-Mobaraki 3
Received: 11 May 2021 / Revised: 17 May 2021 / Accepted: 20 May 2021
© The Author(s), under exclusive licence to the Japan Antibiotics Research Association 2021
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Quote:
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As per data available on 16 May 2021, 100% of 36 early treatment and prophylaxis studies report positive effects (96% of all 55 studies). Of these, 26 studies show statistically significant improvements in isolation. Random effects meta-analysis with pooled effects using the most serious outcome reported 79% and 85% improvement for early treatment and prophylaxis respectively (RR 0.21[0.11–0.37] and 0.15 [0.09–0.25]). The results were similar after exclusion based sensitivity analysis: 81% and 87%(RR 0.19 [0.14–0.26] and 0.13 [0.07–0.25]), and after restriction to 29 peer-reviewed studies: 82% and 88% (RR0.18 [0.11–0.31] and 0.12 [0.05–0.30]). Statistically significant improvements were seen for mortality, ventilation, hospitalization, cases, and viral clearance. 100% of the 17 Randomized Controlled Trials (RCTs) for early treatment and prophylaxis report positive effects, with an estimated improvement of 73% and 83% respectively (RR 0.27[0.18–0.41] and 0.17 [0.05–0.61]), and 93% of all 28 RCTs. These studies are tabulated in Table1. The probability that an ineffective treatment generated results as positive for the 55 studies to date is estimated to be 1 in 23 trillion (p=0.000000000000043). The consistency of positive results across a wide variety of cases has been remarkable. It is extremely unlikely that the observed results could have occurred by chance [8].
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Quote:
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Fig. 1A schematic of the key cellular and biomolecular interactions between Ivermectin, host cell, and SARS-CoV-2 in COVID-19 pathogenesis and prevention of complications. Ivermectin; IVM(red block) inhibits and disrupts binding of the SARS-CoV-2 S protein at the ACE-2 receptors (green).
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I don't know.
Give the article a read and tell me where the authors got it wrong.
-jp
.
__________________
Team JCapper: 2011 PAIHL Regular Season ROI Leader after 15 weeks
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Last edited by Jeff P; 07-18-2021 at 10:10 PM.
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07-18-2021, 10:12 PM
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#9558
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velocitician
Join Date: Aug 2004
Posts: 26,297
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yes that is what the orange one received
__________________
"If this world is all about winners, what's for the losers?" Jr. Bonner: "Well somebody's got to hold the horses Ace."
Last edited by 46zilzal; 07-18-2021 at 10:16 PM.
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07-18-2021, 10:13 PM
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#9559
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velocitician
Join Date: Aug 2004
Posts: 26,297
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Quote:
Originally Posted by xtb
Yes Sherlock, the underlying diseases are very different but the drug does not care what triggers the cytokine response.
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Pathology and treatment NEVER have worked that way..The PATHOLOGTICAL physiological process is what is treated NOT a
__________________
"If this world is all about winners, what's for the losers?" Jr. Bonner: "Well somebody's got to hold the horses Ace."
Last edited by 46zilzal; 07-18-2021 at 10:15 PM.
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07-18-2021, 10:14 PM
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#9560
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Buckle Up
Join Date: Apr 2014
Posts: 10,614
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Quote:
Originally Posted by Jeff P
I don't know.
Give the article a read and tell me where the authors got it wrong.
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Expecting a Dr. Tim attack? When he does, ask him this question: Tim, what does Jan 4, 1934 mean to you?
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07-18-2021, 10:33 PM
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#9561
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velocitician
Join Date: Aug 2004
Posts: 26,297
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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7457938/
a wide variety of meds have "theoretical' treatment aid...VERY FEW long term studies to prove any of them as top choice
__________________
"If this world is all about winners, what's for the losers?" Jr. Bonner: "Well somebody's got to hold the horses Ace."
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07-19-2021, 06:48 AM
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#9562
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Registered User
Join Date: Jun 2008
Posts: 10,172
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Quote:
Originally Posted by 46zilzal
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How does one perform a long term study on drug efficacy in the middle of the crisis. As we all know, if you see this drug working and that other drug not, that's good enough in a crisis. Wouldn't you agree?
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07-19-2021, 08:43 AM
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#9563
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Registered User
Join Date: Dec 2005
Location: Western NY
Posts: 5,345
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Quote:
Originally Posted by 46zilzal
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Please tell us what the current “top choice” med is for treating (not vaccinating against) covid, taking into consideration safety, availablity, cost and effectiveness.
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07-19-2021, 09:18 AM
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#9564
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velocitician
Join Date: Aug 2004
Posts: 26,297
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Quote:
Originally Posted by xtb
Please tell us what the current “top choice” med is for treating (not vaccinating against) covid, taking into consideration safety, availablity, cost and effectiveness.
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I have NEVER been an infectious disease specialist, and retired from practice LONG ago. The way therapeutics changes so rapidly LOOK IT UP YOURSELF
__________________
"If this world is all about winners, what's for the losers?" Jr. Bonner: "Well somebody's got to hold the horses Ace."
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07-19-2021, 09:38 AM
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#9565
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Registered User
Join Date: Dec 2005
Location: Western NY
Posts: 5,345
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Quote:
Originally Posted by 46zilzal
I have NEVER been an infectious disease specialist, and retired from practice LONG ago. The way therapeutics changes so rapidly LOOK IT UP YOURSELF
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We do and keep telling you but your TDS prevents you from accepting it. Get some help.
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07-19-2021, 09:47 AM
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#9566
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velocitician
Join Date: Aug 2004
Posts: 26,297
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Quote:
Originally Posted by xtb
We do and keep telling you but your TDS prevents you from accepting it. Get some help.
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The MULTIPLE articles, written for the prestigious NIH (National Institutes of Health) were written by infectious disease specialists who are also on the"cutting edge" of modern day therapeutics.
I trust THEIR judgement
What is a TDS?
__________________
"If this world is all about winners, what's for the losers?" Jr. Bonner: "Well somebody's got to hold the horses Ace."
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07-19-2021, 10:09 AM
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#9567
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Registered User
Join Date: May 2011
Posts: 22,655
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Quote:
Originally Posted by 46zilzal
The MULTIPLE articles, written for the prestigious NIH (National Institutes of Health) were written by infectious disease specialists who are also on the"cutting edge" of modern day therapeutics.
I trust THEIR judgement
What is a TDS?
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funny, I do not trust everything from Fauci and his NIH
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07-19-2021, 10:28 AM
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#9568
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Registered User
Join Date: Dec 2005
Location: Western NY
Posts: 5,345
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Quote:
Originally Posted by 46zilzal
The MULTIPLE articles, written for the prestigious NIH (National Institutes of Health) were written by infectious disease specialists who are also on the"cutting edge" of modern day therapeutics.
I trust THEIR judgement
What is a TDS?
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You keep a close eye on off-topic, if you are serious and don't know what it means then your mind is really shot.
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07-19-2021, 11:15 AM
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#9569
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Registered User
Join Date: Jun 2008
Posts: 10,172
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Quote:
Originally Posted by 46zilzal
The MULTIPLE articles, written for the prestigious NIH (National Institutes of Health) were written by infectious disease specialists who are also on the"cutting edge" of modern day therapeutics.
I trust THEIR judgement
What is a TDS?
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What does an infectious disease expert know about treatment regimens for various ailments? Their "expertise' is limited to understanding the pathogens themselves. Once that is done, they hand that information off to other specialists who devise treatments regimens. You disagree?
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07-19-2021, 01:08 PM
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#9570
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velocitician
Join Date: Aug 2004
Posts: 26,297
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Quote:
Originally Posted by tucker6
What does an infectious disease expert know about treatment regimens for various ailments? Their "expertise' is limited to understanding the pathogens themselves. Once that is done, they hand that information off to other specialists who devise treatments regimens. You disagree?
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When it is about a VIRAL pandemic....Their expertise is NOT limited to the bugs themselves but to their disposition in populations, how they spread, what autopsy findings are discovered,
It is NOT that compartmentalized, never has been
__________________
"If this world is all about winners, what's for the losers?" Jr. Bonner: "Well somebody's got to hold the horses Ace."
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