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04-26-2022, 08:38 PM
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#16
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Registered User
Join Date: Dec 2001
Location: JCapper Platinum: Kind of like Deep Blue... but for horses.
Posts: 5,258
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CNN | April 25, 2022
FDA approves remdesivir to treat young children with Covid-19:
https://www.cnn.com/2022/04/25/healt...ren/index.html
Quote:
(CNN) The US Food and Drug Administration announced Monday that it has expanded approval of the Covid-19 drug remdesivir to treat patients as young as 28 days and weighing about 7 pounds.
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But a month earlier this little peer reviewed study was published in the International Journal of Infectious Diseases:
Treatment with Ivermectin Is Associated with Decreased Mortality in COVID-19 Patients: Analysis of a National Federated Database:
https://www.ijidonline.com/article/S...21)00988-7/pdf
Quote:
Purpose: To evaluate the difference in mortality of patients treated with ivermectin vs patients treated with remdesivir with COVID-19 in United States using TriNetX Research network, a federated EMR network of over 44 healthcare organizations and 68 million patients from US, from 2009-2021.
Methods & Materials: We retrospectively identified adults (≥18 years) with a recorded COVID-19 infection between January 1, 2020 and July 11, 2021. We compared those with recorded use of ivermectin, but not remdesivir, against those with recorded use of remdesivir, but not ivermectin. We controlled for the following demographics, comorbidities, and treatments that may affect COVID-19 survival outcomes: age, gender, race, ethnicity, nicotine use diabetes mellitus, obesity, chronic lower respiratory disease, ischemic heart diseases, tocilizumab, glucocorticoids, or ventilator use. We measured association with mortality as the primary outcome, with significance assessed at p<0.05.
Results: There were a total of 1,761,060 possible COVID-19 patients based on ICD-10 diagnostic terms and confirmatory lab results. Prior to controlling, our analysis yielded 41,608 patients who had COVID-19 resulting in two unique cohorts that were treated with either ivermectin (1,072) or remdesivir (40,536). Within the ivermectin cohort, average age was 51.9 + 17.8 years, 43% were male, 60% had glucocorticoids and 1% required ventilator support. In the remdesivir cohort, average age was 62.0 + 16.0 years, 54% were male, 64% had glucocorticoids and 2% required ventilator support. After using propensity score matching and adjusting for potential confounders, ivermectin was associated with reduced mortality vs remdesivir (OR 0.308, 95% CI (0.198,0.479)),Risk Difference -5.224%, CI (-7.079%,-3.369%), p <0.0001.
Conclusion: Ivermectin use was associated with decreased mortality in patients with COVID-19 compared to remdesivir. To our knowledge, this is the largest association study of patients with COVID-19, mortality and ivermectin. Further double-blinded placebo-controlled RCTs with large samples are required for definite conclusion. In the future, if more publications are published with the similar result to the current analyses, the certainty of evidence will increase.
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Remember that 'annecdotal report' from January when Ivermectin was offered to the population of an entire city in Brazil?
Looks like it's now undergone peer review.
Ivermectin Prophylaxis Used for COVID-19: A Citywide, Prospective, Observational Study of 223,128 Subjects Using Propensity Score Matching:
https://www.cureus.com/articles/8216...score-matching
Quote:
Abstract
Background: Ivermectin has demonstrated different mechanisms of action that potentially protect from both coronavirus disease 2019 (COVID-19) infection and COVID-19-related comorbidities. Based on the studies suggesting efficacy in prophylaxis combined with the known safety profile of ivermectin, a citywide prevention program using ivermectin for COVID-19 was implemented in Itajaí, a southern city in Brazil in the state of Santa Catarina. The objective of this study was to evaluate the impact of regular ivermectin use on subsequent COVID-19 infection and mortality rates.
Materials and methods: We analyzed data from a prospective, observational study of the citywide COVID-19 prevention with ivermectin program, which was conducted between July 2020 and December 2020 in Itajaí, Brazil. Study design, institutional review board approval, and analysis of registry data occurred after completion of the program. The program consisted of inviting the entire population of Itajaí to a medical visit to enroll in the program and to compile baseline, personal, demographic, and medical information. In the absence of contraindications, ivermectin was offered as an optional treatment to be taken for two consecutive days every 15 days at a dose of 0.2 mg/kg/day. In cases where a participating citizen of Itajaí became ill with COVID-19, they were recommended not to use ivermectin or any other medication in early outpatient treatment. Clinical outcomes of infection, hospitalization, and death were automatically reported and entered into the registry in real time. Study analysis consisted of comparing ivermectin users with non-users using cohorts of infected patients propensity score-matched by age, sex, and comorbidities. COVID-19 infection and mortality rates were analyzed with and without the use of propensity score matching (PSM).
Results: Of the 223,128 citizens of Itajaí considered for the study, a total of 159,561 subjects were included in the analysis: 113,845 (71.3%) regular ivermectin users and 45,716 (23.3%) non-users. Of these, 4,311 ivermectin users were infected, among which 4,197 were from the city of Itajaí (3.7% infection rate), and 3,034 non-users (from Itajaí) were infected (6.6% infection rate), with a 44% reduction in COVID-19 infection rate (risk ratio [RR], 0.56; 95% confidence interval (95% CI), 0.53-0.58; p < 0.0001). Using PSM, two cohorts of 3,034 subjects suffering from COVID-19 infection were compared. The regular use of ivermectin led to a 68% reduction in COVID-19 mortality (25 [0.8%] versus 79 [2.6%] among ivermectin non-users; RR, 0.32; 95% CI, 0.20-0.49; p < 0.0001). When adjusted for residual variables, reduction in mortality rate was 70% (RR, 0.30; 95% CI, 0.19-0.46; p < 0.0001). There was a 56% reduction in hospitalization rate (44 versus 99 hospitalizations among ivermectin users and non-users, respectively; RR, 0.44; 95% CI, 0.31-0.63; p < 0.0001). After adjustment for residual variables, reduction in hospitalization rate was 67% (RR, 0.33; 95% CI, 023-0.66; p < 0.0001).
Conclusion: In this large PSM study, regular use of ivermectin as a prophylactic agent was associated with significantly reduced COVID-19 infection, hospitalization, and mortality rates.
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Quote:
Conclusions
In a citywide ivermectin program with prophylactic, optional ivermectin use for COVID-19, ivermectin was associated with significantly reduced COVID-19 infection, hospitalization, and death rates from COVID-19.
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But I'm sure you're right. All options other than the vaccines are... INCONCEIVABLE.
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-jp
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__________________
Team JCapper: 2011 PAIHL Regular Season ROI Leader after 15 weeks
www.JCapper.com
Last edited by Jeff P; 04-26-2022 at 08:52 PM.
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04-27-2022, 01:55 PM
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#17
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Registered User
Join Date: Aug 2017
Location: Near Lexington, KY
Posts: 3,246
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Quote:
Originally Posted by mostpost
Yeah, they will be tough to convince. Because they are idiots and so are you. Out of 23,122,522 people, 2226 came down with either myocarditis or pericarditis. That is less than one hundredth of one percent.
In the meantime, 6.2 Million people have died worldwide from Covid. And while Mycarditis is a serious disease, it is treatable in most cases and does not have long term effects. The same cannot always be said about Covid 19.
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Triggered Liberal without a COVID Narrative anymore.
Do you know how damned stupid you look calling Jeff P an Idiot???
__________________
Just when you least expect it...just what you least expect-The Pet Shop Boys.
Last edited by Elkchester Road; 04-27-2022 at 01:58 PM.
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04-27-2022, 02:04 PM
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#18
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Ultra MAGA "Gun Bitch"
Join Date: Dec 2005
Location: Western NY
Posts: 5,243
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Quote:
Originally Posted by Elkchester Road
Triggered Liberal without a COVID Narrative anymore.
Do you know how damned stupid you look calling Jeff P an Idiot???
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Musty has no self-awareness, none.
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04-27-2022, 02:32 PM
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#19
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Registered User
Join Date: May 2011
Posts: 22,461
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ivermectin works better than remdesivir?
but surely the drug companies do not make as much money ....
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04-27-2022, 02:32 PM
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#20
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Registered User
Join Date: Aug 2017
Location: Near Lexington, KY
Posts: 3,246
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Quote:
Originally Posted by xtb
Musty has no self-awareness, none.
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__________________
Just when you least expect it...just what you least expect-The Pet Shop Boys.
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04-27-2022, 08:41 PM
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#21
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Registered User
Join Date: Mar 2001
Location: Wisconsin
Posts: 1,819
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yeah sure
Musty must have have been looking in a mirror when he posted that
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04-28-2022, 08:25 AM
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#22
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The Voice of Reason!
Join Date: Mar 2001
Location: Canandaigua, New york
Posts: 112,470
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mostie, care to make yourself look even more stupid?
Asking for a friend.
__________________
Who does the Racing Form Detective like in this one?
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04-28-2022, 06:18 PM
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#23
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Registered User
Join Date: Dec 2001
Location: JCapper Platinum: Kind of like Deep Blue... but for horses.
Posts: 5,258
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Interesting article about Vitamin D3 on the NIH.gov site
COVID-19 Mortality Risk Correlates Inversely with Vitamin D3 Status, and a Mortality Rate Close to Zero Could Theoretically Be Achieved at 50 ng/mL 25(OH)D3: Results of a Systematic Review and Meta-Analysis:
https://pubmed.ncbi.nlm.nih.gov/34684596/
Quote:
Abstract
Background: Much research shows that blood calcidiol (25(OH)D3) levels correlate strongly with SARS-CoV-2 infection severity. There is open discussion regarding whether low D3 is caused by the infection or if deficiency negatively affects immune defense. The aim of this study was to collect further evidence on this topic.
Methods: Systematic literature search was performed to identify retrospective cohort as well as clinical studies on COVID-19 mortality rates versus D3 blood levels. Mortality rates from clinical studies were corrected for age, sex, and diabetes. Data were analyzed using correlation and linear regression.
Results: One population study and seven clinical studies were identified, which reported D3 blood levels preinfection or on the day of hospital admission. The two independent datasets showed a negative Pearson correlation of D3 levels and mortality risk (r(17) = -0.4154, p = 0.0770/r(13) = -0.4886, p = 0.0646). For the combined data, median (IQR) D3 levels were 23.2 ng/mL (17.4-26.8), and a significant Pearson correlation was observed (r(32) = -0.3989, p = 0.0194). Regression suggested a theoretical point of zero mortality at approximately 50 ng/mL D3.
Conclusions: The datasets provide strong evidence that low D3 is a predictor rather than just a side effect of the infection. Despite ongoing vaccinations, we recommend raising serum 25(OH)D levels to above 50 ng/mL to prevent or mitigate new outbreaks due to escape mutations or decreasing antibody activity.
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Wait... Is the NIH spreading Covid disinformation?
-jp
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__________________
Team JCapper: 2011 PAIHL Regular Season ROI Leader after 15 weeks
www.JCapper.com
Last edited by Jeff P; 04-28-2022 at 06:24 PM.
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04-28-2022, 07:10 PM
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#24
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PA Steward
Join Date: Mar 2001
Location: Del Boca Vista
Posts: 88,183
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No, they're just living up to the non-disclosure agreement they signed with Pfizer....don't start talking about stuff like this until sales start to slack off...then you can do what you want....
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04-28-2022, 07:52 PM
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#25
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Registered User
Join Date: Nov 2012
Location: Bakersfield, CA
Posts: 1,791
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Quote:
Originally Posted by mostpost
Yeah, they will be tough to convince. Because they are idiots and so are you. Out of 23,122,522 people, 2226 came down with either myocarditis or pericarditis. That is less than one hundredth of one percent.
In the meantime, 6.2 Million people have died worldwide from Covid. And while Mycarditis is a serious disease, it is treatable in most cases and does not have long term effects. The same cannot always be said about Covid 19.
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If you think 6.2 million people really died from COVID you are a freaking retard.
I had the head of nursing from of a local hospital tell me direct (like face to face tell me) 30 days ago that the hospital/ medical examiner is still labeling people as COVID 19 deaths as an insurance/ payment scam. Every death in the hospital is tested for COVID, and every positive test gets labeled as a COVID death. Car accident, stroke, heart attack, even cancer, DOES NOT MATTER. If they have COVID 19 or even throw a false positive on a test (they test the patients when they arrive and sometimes daily while they are at the facility) the hospital pursues it as a COVID death. She even pointed out that the reimbursement rates for PPE COVID supplies is a money maker for the hospital, so the hospital tests like crazy for positive patients so that they can hit insurance companies and the governments for big reimbursements on those supplies.
She even told me that they pursue COVID designations for people that have tested positive at any time within 30 days of their death. Reimbursements and payments/ grants to hospitals can be based on that. So if a patient dies, they go back and call their doctor and check their records for positive tests within the last 30 days.
Oh and BTW her income nearly doubled in 2020 & 2021 because of the overtime and the special rates they get to bill during COVID. It's a total free for all.
I know this to be true because I do her income taxes.
After hearing this straight from the horses mouth I cannot buy the COVID kool aid anymore, I just can't.
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04-29-2022, 12:49 AM
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#26
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Registered User
Join Date: Aug 2017
Location: Near Lexington, KY
Posts: 3,246
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Quote:
Originally Posted by Rex Phinney
If you think 6.2 million people really died from COVID you are a freaking retard.
I had the head of nursing from of a local hospital tell me direct (like face to face tell me) 30 days ago that the hospital/ medical examiner is still labeling people as COVID 19 deaths as an insurance/ payment scam. Every death in the hospital is tested for COVID, and every positive test gets labeled as a COVID death. Car accident, stroke, heart attack, even cancer, DOES NOT MATTER. If they have COVID 19 or even throw a false positive on a test (they test the patients when they arrive and sometimes daily while they are at the facility) the hospital pursues it as a COVID death. She even pointed out that the reimbursement rates for PPE COVID supplies is a money maker for the hospital, so the hospital tests like crazy for positive patients so that they can hit insurance companies and the governments for big reimbursements on those supplies.
She even told me that they pursue COVID designations for people that have tested positive at any time within 30 days of their death. Reimbursements and payments/ grants to hospitals can be based on that. So if a patient dies, they go back and call their doctor and check their records for positive tests within the last 30 days.
Oh and BTW her income nearly doubled in 2020 & 2021 because of the overtime and the special rates they get to bill during COVID. It's a total free for all.
I know this to be true because I do her income taxes.
After hearing this straight from the horses mouth I cannot buy the COVID kool aid anymore, I just can't.
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Rex Phinney...thank you for your post. All of this shit is what it is. As time passes and we move further from Pandemic...more and more things will become clear. The people on the wrong side of this deserve everything that is coming their way.
__________________
Just when you least expect it...just what you least expect-The Pet Shop Boys.
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04-29-2022, 12:53 AM
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#27
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velocitician
Join Date: Aug 2004
Posts: 26,248
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measles cases on he rise
__________________
"If this world is all about winners, what's for the losers?" Jr. Bonner: "Well somebody's got to hold the horses Ace."
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04-29-2022, 12:56 AM
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#28
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Registered User
Join Date: Aug 2017
Location: Near Lexington, KY
Posts: 3,246
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Quote:
Originally Posted by 46zilzal
measles cases on he rise
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W H A T E V E R
__________________
Just when you least expect it...just what you least expect-The Pet Shop Boys.
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04-29-2022, 09:00 AM
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#29
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Ultra MAGA "Gun Bitch"
Join Date: Dec 2005
Location: Western NY
Posts: 5,243
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Quote:
Originally Posted by 46zilzal
measles cases on he rise
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Cucking still on "he" rise.
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04-29-2022, 09:39 AM
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#30
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Registered User
Join Date: Nov 2009
Location: donkeys ride from ASD
Posts: 12,995
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Quote:
Originally Posted by xtb
Dumbass
While heartbreaking for the families, the vast majority of supposed chinavirus deaths occur in people well past the average life expectancy and/or with multiple comorbidities. The vast majority of people killed or injured by the chinavirus shots are healthy young adults. These people died needlessly because they succumbed to the pressure or mandates to get the experimental shot. You think the thousands of people killed by the shots is insignificant but when a handful of black people are killed by police when resisting arrest, this country is turned upside down. You truly are a dumbass.
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FACT!!!
__________________
'complicated business folks, complicated business.'
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