I think it depends on how much track specific information you use in your game. If a lot of your plays involve trainers, trainer jockey combos, understanding the post position and other biases at a track, you'll be at a disadvantage at tracks you don't know at well.
These days, I think the goal should probably be to try to focus on smaller and mid sized tracks. I don't have data to support this, but when I play stakes I feel like I can find live horses at way better prices at the non major tracks on both coasts.
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