Link to the CDC.gov page about Moderna's bivalent booster --
Booster Doses of Moderna COVID-19 Vaccines in Adults, Adolescents & Children
https://www.cdc.gov/vaccines/acip/me...Miller-508.pdf
Reading the CDC's write-up something really sticks out.
The number of mice in the Omicron BA.4/BA.5 bivalent vaccine trial: 10
On page 21 there's a chart showing the 10 mice did show an increase in antibodies.
Seems promising. Thus the basis for EUA approval of Moderna's bivalent booster.
But then on page 22 there's a chart showing that all 10 mice in the Omicron BA.4/BA.5 bivalent vaccine trial became infected when 'challenged' with Omicron BA.5 four weeks after getting a booster.
clickable thumbnail below
What does the screenshot show?
The dots show viral counts in the lungs and noses of all 10 mice.
All 10 mice received a 2 dose primary series of the original Moderna vaccine, were then boosted with the Omicron BA.5 based bivalent booster, and were 'challenged' four weeks later by exposure to Omicron BA.5
If all 10 of these super-protected mice caught Covid anyway:
Is there a reason to expect a significantly better outcome for humans?
-jp
.
