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I am up lifetime in pick 4s and up only because of a single. I hit a 4K+ pick 4 because of a single that I owned that won nicely at 9-2. Funny, it was a low level claimer that I made more $ on the pick 4 wager than the purse money after paying jock and trainer.
I only play a pick 3/4+ if I have a single. As you said, it gets too expensive when you start spreading in each leg. My favorite pick 4 is when I get a solid single (that is not a prohibitive favorite) that has a "chaos" race or 2 apart of the sequence, where you can spread, and stand to cash with a 10-1+ winner apart of it.
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