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I've done a lot of testing of win wagers over the years and if the goal is to find a profitable method that doesn't require long hours of traditional pp handicapping (in other words, using a computer), the profitable ROI tests tend to have win percentages between 10 and 20%. This, of course, means that although the end result is positive (ROI), long run outs are expected. You could adjust the method to include more favorites to try and increase the win percentage to keep your sanity, but that always ends up significantly reducing the ROI.
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