Interesting thread (in English) that sheds some light on why each new Omicron variant might be hitting the vaccinated in the Netherlands harder than the previous one:
https://nitter.net/rintrahradagast/s...90966511001602
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So what could possibly be the reason? Well, Urk is a perfect demonstration of my theory: Unvaccinated communities will have a big Omicron wave, followed by widespread immunity against Omicron, preventing waves of new Omicron variants.
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We can check this by simply looking at Urk's sewage concentrations over time. It becomes clear they had a big Omicron wave, followed by no additional waves. Their BA.1 wave caused widespread strong broad immunity against other Omicron variants.
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And if you look at a highly vaccinated & boosted and relatively well connected municipality like Voorschoten, you see a currently ongoing Omicron wave that is as big as the original BA.1 wave:
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What does all of this suggest? It suggests original antigenic sin, a process induced by vaccination whereby the body responds to BA.1 infections with an immune response that can be easily escaped by other Omicron variants through a small number of mutations.
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This doesn't just explain why the least vaccinated Dutch municipality has the least SARS-COV-2 RNA in its sewage. It explains why a ~15% vaccinated country like Algeria has not really seen any real COVID waves since march:
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-jp
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