Have a look at Libre Office (or any of the Open Office forks).
They allow at least 1024 columns in the spreadsheet and integrate well with the database. Your MS office skills will translate and they're free.
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The great menace to progress is not ignorance but the illusion of knowledge - Daniel J. Boorstin
The takers get the honey, the givers sing the blues - Robin Trower, Too Rolling Stoned - 1974
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